Myofilament Calcium-Buffering Dependent Action Potential Triangulation in Human-Induced Pluripotent Stem Cell Model of Hypertrophic Cardiomyopathy.

Lili Wang,Dmytro O Kryshtal,Kyungsoo Kim,Shan Parikh,Adrian Gabriel Cadar,Kevin Richard Bersell,Huan He,Jose R Pinto,Bjorn C Knollmann

Journal of the American College of Cardiology（2017）

引用 16|浏览22

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摘要

Familial hypertrophic cardiomyopathy is caused by mutations in genes encoding sarcomere proteins. Among hypertrophic cardiomyopathy–linked disease genes, cardiac troponin T (TnT) mutations are associated with a high incidence of arrhythmic cardiac death [(1)][1], but the underlying mechanism has

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