A Review Of Connectivity Map And Computational Approaches In Pharmacogenomics (Bbw112, 2017)
BRIEFINGS IN BIOINFORMATICS(2017)
摘要
Large-scale perturbation databases, such as Connectivity Map (CMap) or Library of Integrated Network-based Cellular Signatures (LINCS), provide enormous opportunities for computational pharmacogenomics and drug design. A reason for this is that in contrast to classical pharmacology focusing at one target at a time, the transcriptomics profiles provided by CMap and LINCS open the door for systems biology approaches on the pathway and network level. In this article, we provide a review of recent developments in computational pharmacogenomics with respect to CMap and LINCS and related applications.
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关键词
pharmacogenomics,drug discovery,bioinformatics,drug repurposing,drug repositioning,big data
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