Tumor Stiffness Extends Its Grip On The Metastatic Microenvironment
MOLECULAR & CELLULAR ONCOLOGY(2017)
摘要
The increased stiffness of a tumor triggers a multitude of responses that aid cancer cell dissemination. Stiffness-induced expression of CCN1 mediates autocrine signaling in the endothelium to upregulate N-Cadherin levels. This permits more stable interactions with cancer cells and increases their ability to spread into the circulation.
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关键词
CYR61/CCN1, blood vessels, stiffness, cancer metastasis, proteomics
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