Development of an in vivo model of Chlamydia abortus chronic infection in mice overexpressing IL-10.

Laura Del Río,Antonio Murcia,Antonio J Buendía,Daniel Álvarez,Nieves Ortega,José A Navarro,Jesús Salinas,María Rosa Caro

Veterinary Microbiology（2018）

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摘要

•An in vivo model for chronic Chlamydia abortus infection is proposed.•IL-10 overexpressing transgenic mice showed a long-term infection with C. abortus.•Defective C. abortus clearance was associated to an impaired recruitment of macrophages and iNOS activity.

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关键词

Chlamydia abortus,IL-10,Chronic infection,Macil10tg mice

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