Multiple Sclerosis Lesion Segmentation Using Improved Convolutional Neural Networks

The Multiple Sclerosis (MS) lesion segmentation is critical for the diagnosis, treatment and follow-up of the MS patients. Nowadays, the MS lesion segmentation in Magnetic Resonance Image (MRI) is a time-consuming manual process carried out by medical experts, which is subject to intra- and inter- expert variability. Machine learning methods including Deep Learning has been applied to this problem, obtaining solutions that outperformed other conventional automatic methods. Deep Learning methods have especially turned out to be promising, attaining human expert performance levels. Our aim is to develop a fully automatic method that will help experts in their task and reduce the necessary time and effort in the process. In this paper, we propose a new approach based on Convolutional Neural Networks (CNN) to the MS lesion segmentation problem. We study different CNN approaches and compare their segmentation performance. We obtain an average dice score of 57.5% and a true positive rate of 59.7% for a real dataset of 59 patients with a specific CNN approach, outperforming the other CNN approaches and a commonly used automatic tool for MS lesion segmentation.