Extension of the Hansen solubility parameter concept to the micronization of cyclotrimethylenetrinitramine crystals by supercritical anti-solvent process

•Interpretations were proposed for different RDX crystals obtained by the SAS process.•Solubility parameter concept was used to explain crystallization above the mixture critical point.•Phase equilibria were related to agglomeration below the mixture critical point.•Optimum values of the operating parameters for the micronization were deduced.