Interferon induced Mx protein from Indian snow trout Schizothorax richardsonii (Gray) lacks critical functional features unlike its mammalian homologues.

•Snow trout Mx protein carries the signature of dynamin family (LPRGTGIVTR) and a tripartite GTP-binding domain (GDQSSGKS, DLPG, and TKPD).•Mx protein is an elongated structure with a G domain, bundle signaling element (BSE) and a GTPase effector domain with two highly conserved leucine zippers at C treminal.•Snow trout Mx lacks the crucial functional features of its mammalian homologues.•A potential ligand binding site was identified in G-domain of Mx.