Molecular analysis of heavy chain-only antibodies of
Biochemistry (Moscow)(2014)
摘要
In this work, IgG content and structures of antigen-binding domains and hinge regions of different IgG subtypes of were analyzed in detail for the first time. Our data demonstrate that contains a very large amount of heavy chain-only antibodies that can be used as a source of VHH domain-containing molecules. Despite some minor sequence differences identified in this study, VHH domains possess principally the same unique features as those of and the llama. These features are important for developing an efficient phage display-based anti- body selection technology. We conclude that is a very suitable animal to raise an immune response that serves as a source to identify antigen-specific VHHs selected after phage display.
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关键词
antibody,IgG,variable domain,single-domain antibody
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