Precision medicine in age-specific non-small-cell-lung-cancer patients: Integrating biomolecular results into clinical practice-A new approach to improve personalized translational research.

•The youthful lung cancer may constitute a different clinical-pathologic entity.•Nowadays, patients younger than 40 years are treated similarly to oldest ones.•NGS approach allows for a genetic characterization of NSCLC young adult patients.•Genetic profiles among young and old patients and the healthy cohort were analyzed.•TP53, EGFR,KRAS alterations may be involved in early onset of youthful lung cancer.