5-HT7 receptor-mediated fear conditioning and possible involvement of extracellular signal-regulated kinase

•Activation of 5-HT7 receptors is critical for emotional learning and memory.•5-HT7 receptor-mediated ERK signaling in the amygdala is involved in context- and tone-dependent fear memory.•Hippocampal ERK signaling plays a reciprocal role to that in the amygdala in context-dependent fear memory.