Silibinin induces hepatic stellate cell cycle arrest via enhancing p53/p27 and inhibiting Akt downstream signaling protein expression.

Devaraj Ezhilarasan,Jonathan Evraerts,Brice Sid,Pedro Buc Calderon,Sivanesan Karthikeyan,Etienne Sokal,Mustapha Najimi

Hepatobiliary & Pancreatic Diseases International（2017）

引用 34|浏览11

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摘要

The anti-proliferative effect of silibinin on LX-2 human stellate cells is via the inhibition of the expressions of various cell cycle targets including p27, Akt and sirtuin signaling.

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关键词

silibinin,hepatic stellate cells,in vitro,cell cycle arrest,proliferation

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