Soluble P-selectin rescues mice from anthrax lethal toxin-induced mortality through PSGL-1 pathway-mediated correction of hemostasis

Yao-Wen Chang
Yao-Wen Chang
Pei-Hsun Ho
Pei-Hsun Ho
Yin-Jeh Tzeng
Yin-Jeh Tzeng

Virulence, Volume 8, Issue 7, 2017, Pages 1216-1228.

Cited by: 1|Bibtex|Views26|DOI:https://doi.org/10.1080/21505594.2017.1282027
WOS
Other Links: pubmed.ncbi.nlm.nih.gov|academic.microsoft.com

Abstract:

As one of the virulence factors of Bacillus anthracis, lethal toxin (LT) induces various pathogenic responses including the suppression of the coagulation system. In this study, we observed that LT markedly increased the circulating soluble P-selectin (sP-sel) levels and microparticle (MP) count in wild-type but not P-selectin (P-sel, Sel...More

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