Hepatic S6K1 Partially Regulates Lifespan of Mice with Mitochondrial Complex I Deficiency.

Takashi K Ito
Takashi K Ito
Chenhao Lu
Chenhao Lu
Jacob Khan
Jacob Khan
Quy Nguyen
Quy Nguyen
Heather Z Huang
Heather Z Huang
Dayae Kim
Dayae Kim
Jo Tan
Jo Tan
Yenna Lee
Yenna Lee
Tuyet Nguyen
Tuyet Nguyen
Samy Khessib
Samy Khessib
Natalie Lim
Natalie Lim

Frontiers in genetics, (2017): 113

Cited by: 0|Views5
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Abstract:

The inactivation of ribosomal protein S6 kinase 1 (S6K1) recapitulates aspects of caloric restriction and mTORC1 inhibition to achieve prolonged longevity in invertebrate and mouse models. In addition to delaying normative aging, inhibition of mTORC1 extends the shortened lifespan of yeast, fly, and mouse models with severe mitochondrial ...More

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