Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site

Eva-Maria Strauch,Steffen M Bernard,David La, Alan J Bohn,Peter S Lee,Caitlin E Anderson,Travis Nieusma,Carly A Holstein,Natalie K Garcia,Kathryn A Hooper,Rashmi Ravichandran,Jorgen W Nelson,William Sheffler,Jesse D Bloom,Kelly K Lee,Andrew B Ward,Paul Yager,Deborah H Fuller,Ian A Wilson,David Baker

NATURE BIOTECHNOLOGY（2017）

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摘要

method to target trimeric membrane proteins by designing geometrically matched trimeric protein binders is demonstrated for the influenza-virus glycoprotein hemagglutinin.

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关键词

Molecular engineering,Protein design,Life Sciences,general,Biotechnology,Biomedicine,Agriculture,Biomedical Engineering/Biotechnology,Bioinformatics

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