Epitope-dependent mechanisms of CD27 neutralization revealed by X-ray crystallography.

Galina Obmolova,Alexey Teplyakov,Thomas J Malia, Nicole Wunderler,Deborah Kwok,Linda Barone,Raymond Sweet,Tatiana Ort,Michael Scully,Gary L Gilliland

Molecular Immunology（2017）

引用 7|浏览0

暂无评分

摘要

•Two anti-CD27 antibodies exhibit distinctly different pharmacokinetics in monkeys.•Crystal structure of CD27 with both mAbs reveals their non-overlapping epitopes.•The different neutralization mechanisms of the two mAbs are linked to the epitopes.

查看译文

关键词

ADCC,CRD,ECD,EDTA,ELISA,mAb,HRP,PBS,PDB,PEG,PK,SEC,SEM,SPR,TNF,RMSD

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要