A single nucleotide polymorphism of cyclin-dependent kinase inhibitor 1B (p27) associated with human vein graft failure affects growth of human venous adventitial cells but not smooth muscle cells.
Journal of Vascular Surgery(2018)
摘要
These results support the functionality of the p27 SNP in venous SMCs and adventitial cells, but an effect of the SNP on cell proliferation is limited to only adventitial cells. These data point to a potential role for adventitial cells in human vein graft failure and also suggest that SMCs express factors that interfere with the activity of p27.
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