Direct-acting antiviral therapy enhances total CD4+ and CD8+ T-cells responses, but does not alter T-cells activation among HCV mono-infected, and HCV/HIV-1 co-infected patients.

Saeid Najafi Fard,Ivan Schietroma,Giuseppe Corano Scheri,Noemi Giustini,Sara Serafino,Eugenio Nelson Cavallari,Claudia Pinacchio,Gabriella De Girolamo,Giancarlo Ceccarelli,Carolina Scagnolari,Vincenzo Vullo,Gabriella d'Ettorre

Clinics and Research in Hepatology and Gastroenterology（2018）

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摘要

Total T-cells immune response enhances after therapy, however, the state of immune activation may remain elevated for a longtime after the end of treatment and contribute to post-Sustained Virologic Response (SVR) consequences.

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关键词

Hepatitis C virus,Human immunodeficiency virus-1,Direct-acting antiviral,T-cell,Immune activation,Intracellular cytokine assay

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