Phosphoinositide-dependent protein kinase 1 is a potential novel therapeutic target in mantle cell lymphoma.
Experimental Hematology(2018)
摘要
•3-Phosphoinositide-dependent protein kinase 1 (PDPK1) is found to be constitutively activated in various types of patient-derived B-cell non-Hodgkin lymphoma cells, including mantle cell lymphoma (MCL), which remains a highly treatment-refractory disease subtype.•PDPK1 plays pivotal roles in the proliferation and survival of tumor cells of MCL-derived cell lines.•PDPK1 is suggested to be a potential therapeutic target in MCL.
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关键词
PDPK1,RSK2,mantle cell lymphoma,molecular target
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