CXCR3 blockade combined with cyclosporine A alleviates acute graft-versus-host disease by inhibiting alloreactive donor T cell responses in a murine model.

•CXCR3 antagonist together with CsA had a synergy effect to mitigate aGvHD in a murine aGvHD model.•The mechanism relied on inhibiting of donor-derived T cell responses.•AMG487 combined with CsA decreased the oncentrations of pro-inflammatory cytokines in serum.