Symmetry assisted tuning of bending and brittle multi-component forms of probenecid.
CHEMICAL COMMUNICATIONS(2017)
摘要
The mechanical flexibility known in the antihyperuricemia drug probenecid has been extended into multi-component systems using co-formers with two donor or acceptor sites, in contrast to systems with a single H-bond acceptor that exhibit brittle behaviour. The piperazinium salt demonstrates that GRAS co-formers can be used to maintain mechanical flexibility with drug molecules.
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