Phenylquinoline transient receptor potential vanilloid 1 antagonists for the treatment of pain: Discovery of 1-(2-phenylquinoline-4-carbonyl)-N-(4-(trifluoromethyl)phenyl)pyrrolidine-3-carboxamide.

Amining to develop pharmacological and improve aqueous solubility, we have identified series of TRPV1 antagonists bearing phenylquinoline moiety, exemplified by the antinoceptive potent and solubility antagonist 37.