Influenza A(H5N1) Virus Infection in a Child With Encephalitis Complicated by Obstructive Hydrocephalus.

Gannon Chun Kit Mak,Mike Yat-Wah Kwan,Chris Ka Pun Mok,Janice Yee Chi Lo,Malik Peiris,Chi Wai Leung

CLINICAL INFECTIOUS DISEASES（2018）

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摘要

A 2-year-old boy with highly pathogenic avian influenza A(H5N1) virus infection with minimal respiratory symptoms developed encephalitis complicated by obstructive hydrocephalus. Viral RNA was detectable in cerebrospinal fluid. The virus belonged to H5N1 clade 2.3.2.1b and had acquired the mammalian adaptation mutation PB2 Q591K.

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avian influenza,central nervous system infection,H5N1,hydrocephalus

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