Biased Expression of the FOXP3Δ3 Isoform in Aggressive Bladder Cancer Mediates Differentiation and Cisplatin Chemotherapy Resistance.

Hanwei Zhang,Kris Prado,Kelvin X Zhang,Elizabeth M Peek,Jane Lee,Xiaoyan Wang,Jiaoti Huang,Gang Li,Matteo Pellegrini,Arnold I Chin

Clinical cancer research : an official journal of the American Association for Cancer Research（2016）

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摘要

(i) Biased expression of the FOXP3Δ3 isoform in bladder cancer inversely correlates with overall survival, (ii) FOXP3Δ3 induces a unique gene program that mediates cancer differentiation, and (iii) FOXP3Δ3 may augment chemotherapy resistance. Clin Cancer Res; 22(21); 5349-61. ©2016 AACR.

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