Minocycline diminishes the rotenone induced neurotoxicity and glial activation via suppression of apoptosis, nitrite levels and oxidative stress.

Dinesh Kumar Verma,Dhirendra Kumar Singh,Sonam Gupta,Parul Gupta,Abhishek Singh,Joyshree Biswas,Sarika Singh

NeuroToxicology（2018）

引用 17|浏览20

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摘要

•Minocyclin inhibits rotenone induced oxidative stress and increased nitrite levels.•It inhibits augmented glial cell reactivity and DNA fragmentation.•Minocycline inhibits the degenerative apoptotic neuronal death.

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关键词

Minocycline,Rotenone,Neuronal death,Nitric oxide,Oxidative stress,Apoptosis

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