HIPK2 polymorphisms rs2058265, rs6464214, and rs7456421 were associated with kidney stone disease in Chinese males not females.

Haisong Lin,Xiujuan Zhu,Jun Long,Yang Chen,Yuanliang Xie,Ming Liao,Jianxin Chen,Jiarong Tian,Shengzhu Huang,Ruiqiang Tang,Xiaoying Xian,Suchun Wei,Qiuyan Wang,Zengnan Mo

Gene（2018）

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摘要

•In the first time we found that HIPK2 polymorphisms associated with increased KSD risk in males.•HIPK2 polymorphisms is linked with Cr and UA levels in the Chinese population, which might contributed to the kidney stone formation.•HIPK2 might up-regulate AR signaling, and which might contribute to the kidney stone formation.

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关键词

HIPK2,KSD,SBP,Cr,UA,Ur,TC(CHOL),TG,RTECs

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