A New Ratiometric Lysosomal Copper(Ii) Fluorescent Probe To Map A Dynamic Metallome In Live Cells

Maria Laura Giuffrida,Giuseppe Trusso Sfrazzetto,Cristina Satriano,Stefania Zimbone,Gaetano A Tomaselli,Agata Copani,Enrico Rizzarelli

INORGANIC CHEMISTRY（2018）

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摘要

We synthesized a new ratiometric fluorescent Cu2+ probe, bearing a morpholine moiety for selective binding to lysosomes and two picolylamine arms for the specific chelation of divalent copper ions. The probe capability to detect lysosomal Cu2+ was demonstrated in human differentiated neuroblastoma cells by confocal microscopy.

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