Soluble endoglin and hypercholesterolemia aggravate endothelial and vessel wall dysfunction in mouse aorta.

Barbora Vitverova,Katerina Blazickova,Iveta Najmanova,Matej Vicen,Radek Hyšpler,Eva Dolezelova,Ivana Nemeckova,Jurjen Duintjer Tebbens,Carmelo Bernabeu,Miguel Pericacho,Petr Nachtigal

Atherosclerosis（2018）

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摘要

•Soluble endoglin (sEng) is a biomarker of cardiovascular disorders (CVD).•Soluble endoglin and hypercholesterolemia aggravate endothelial and vessel wall dysfunction.•sEng and hypercholesterolemia impair membrane endoglin/eNOS signaling in endothelium.•Combination of hypercholesterolemia and high levels of sEng represents a risk factor of CVD.

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关键词

Soluble endoglin,Endothelial dysfunction,eNOS,Vascular reactivity,Mice

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