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Supradural inflammatory soup in awake and freely moving rats induces facial allodynia that is blocked by putative immune modulators.

Julie Wieseler,Amanda Ellis,Andrew McFadden, Kendra Stone,Kimberley Brown, Sara Cady,Leandro F Bastos,David Sprunger,Niloofar Rezvani,Kirk Johnson,Kenner C Rice,Steven F Maier,Linda R Watkins

Brain Research（2017）

Cited 19|Views16
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Abstract
•Migraine facial allodynia was modeled in male rats by supradural “inflammatory soup”.•Proinflammatory mRNAs increased in trigeminal n. caudalis as a result.•Facial allodynia was prevented by 3 chemically diverse glial modulatory drugs.
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AUC,DAMPs,DRG,HMGB1,IL-1,MIF,Sp5C,TLR4,TNF
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