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Variations of isovaline structure related to activity in the formalin foot assay in mice.

Amino acids, no. 7 (2017): 1203-1213

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Abstract

Current centrally acting analgesics such as opioids are associated with adverse effects that limit their use and threaten patient safety. Isovaline is a novel prototype analgesic that produces peripheral antinociception in several pain models with little or no effect on the central nervous system. The aim of this study was to establish a ...More

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