Prospective intra-individual comparison of standard dose versus reduced-dose thoracic CT using hybrid and pure iterative reconstruction in a follow-up cohort of pulmonary nodules-Effect of detectability of pulmonary nodules with lowering dose based on nodule size, type and body mass index.

•Dose reduction should be tailored to patient’s size, indication and reconstruction algorithms.•Low-dose thoracic CT with fixed tube current (CTDIvol 0.3mGy) impacts accuracy in large patients.•Being aware of limitations of low-dose approaches will ensure quality and accuracy.•Protocols must be based on individual patients and clinical indication.