Nesfatin-1 and visfatin expression is associated with reduced atherosclerotic disease risk in patients with rheumatoid arthritis

Chanel Robinson,Linda Tsang,Ahmed Solomon,Angela J. Woodiwiss,Sule Gunter,Mervyn Mer,Hon-Chun Hsu,Monica Gomes,Gavin R. Norton,Aletta M.E. Millen, P.H. Dessein

Peptides（2018）

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摘要

•Visfatin levels were associated with cardio-metabolic risk in RA.•Nesfatin concentrations were related to reduced carotid IMT in RA.•Nesfatin and visfatin associated with the plaque stability mediator MMP-2 in RA.•Nesfatin and visfatin concentrations were directly correlated in RA.•MMP-2 expression in relation to visfatin may represent a compensatory mechanism in RA.

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关键词

Visfatin,Nesfatin,Rheumatoid arthritis,Atherosclerosis,Plaque vulnerablility

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