The Effect of Geometric Isomerism on the Anticancer Activity of the Monofunctional Platinum Complex Trans-[Pt(nh3)2(phenanthridine)cl]no3.

A trans-DDP based monofunctional phenanthridine Pt(ii) complex was synthesized and characterized. Its anticancer activity was studied in vitro on a panel of human cancer cell lines and mouse intestinal cancer organoids. This complex displays significant antitumor properties, with a different spectrum of activity than that of classic bifunctional cross-linking agents like cisplatin.