Cytosolic tryparedoxin of Leishmania donovani modulates host immune response in visceral leishmaniasis.

Shashi Shekhar Suman,Ajay Amit,Krishn Pratap Singh,Parool Gupta,Asif Equbal,Arti Kumari,Roshan Kamal Topno,Vidyananda Ravidas,Krishna Pandey,Sanjiva Bimal,Pradeep Das,Vahab Ali

Cytokine（2018）

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摘要

•Cytosolic tryparedoxin (cTXN) is a crucial oxidoreductase protein of thiol metabolic cascade.•cTXN protein supplementation enhances in vitro growth rate of L. donovani promastigotes.•It modulates the disease outcome by shifting immune response towards Th2 arm of adaptive immunity.

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关键词

Tryparedoxin,Cytokines,Acid phosphatase,Host immune response,Leishmania parasites,ROS

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