TRPM8 and RAAS-mediated hypertension is critical for cold-induced immunosuppression in mice

Oncotarget, Volume 9, Issue 16, 2018, Pages 12781-12795.

Cited by: 0|Bibtex|Views2|DOI:https://doi.org/10.18632/oncotarget.24356
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Other Links: pubmed.ncbi.nlm.nih.gov|academic.microsoft.com

Abstract:

Mechanisms underlying cold-induced immunosuppression remain unclear. Here we found that cold exposure leads to transient receptor potential melastatin 8 (TRPM8)-dependent, renin-angiotensin-aldosterone system (RAAS)-mediated hypertension, which subsequently induces small molecule and fluid extravasation, increases plasma Ig levels, and el...More

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