TRPM8 and RAAS-mediated hypertension is critical for cold-induced immunosuppression in mice
Oncotarget, Volume 9, Issue 16, 2018, Pages 12781-12795.
Mechanisms underlying cold-induced immunosuppression remain unclear. Here we found that cold exposure leads to transient receptor potential melastatin 8 (TRPM8)-dependent, renin-angiotensin-aldosterone system (RAAS)-mediated hypertension, which subsequently induces small molecule and fluid extravasation, increases plasma Ig levels, and el...More
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