Cross-Reactive Antibody Responses To Novel H5nx Influenza Viruses Following Homologous And Heterologous Prime-Boost Vaccination With A Prepandemic Stockpiled A(H5n1) Vaccine In Humans
JOURNAL OF INFECTIOUS DISEASES(2017)
摘要
Recently, novel highly pathogenic avian influenza H5Nx viruses (clade 2.3.4.4) caused outbreaks in US poultry. We evaluated the potential of a stockpiled A(H5N1) A/Anhui/1/2005 (clade 2.3.4) vaccine to elicit cross-reactive antibody responses to these emerging viruses. Sera from subjects who received 2 doses of MF59-adjuvanted A/Anhui/1/2005, or 1 dose of MF59-adjuvanted A/Anhui/1/2005 following priming with a clade 1 vaccine were characterized by microneutralization assays and modified hemagglutination inhibition (HI) assays. Only heterologous prime-boost vaccination induced modest cross-reactive HI antibody responses to H5Nx viruses. Heterologous prime-boost may provide a more effective vaccination strategy to broaden the antibody responses to emerging viruses.
更多查看译文
关键词
highly pathogenic avian influenza viruses, pre-pandemic stockpile, antibody responses
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要