Stat3 phosphorylation is required for embryonic stem cells ground state maintenance in 2i culture media

ONCOTARGET, pp. 31227-31237, 2017.

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Abstract:

Embryonic stem cells (ES cells) can be maintained its undifferentiated state with feeder cells or LIF, which can activate Jak/Stat3 pathway. Recently, it has been reported a new culture condition comprising serum-free medium with ERK and GSK3 beta inhibitors (2i) could drive ES cells into a state of pluripotency more like inner cell mass ...More

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