A novel device for continuous long-term electroencephalogram recording and drug administration in mice with a nice, powerful and sophisticated wired system.

Shigeru Watanabe,Masanori Saito, Masaki Soma,Hitoshi Miyaoka,Masami Takahashi

Journal of Neuroscience Methods（2017）

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摘要

•We constructed a sophisticated device for long term EEG recording and drug infusion in moving mice.•Continuous EEG recording was recorded for up to 63 days.•Continuous drug infusion with EEG recording was succeeded for up to 22 days.•The device will be useful to develop new antiepileptic drugs.

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关键词

Epilepsy,Antiepileptic drug,Epileptogenesis,Epileptic maturation,Long-term drug administration,Electroencephalogram,Free-moving mouse

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