Exogenous SERP1 attenuates restenosis by restoring GLP-1 receptor activity in diabetic rats following vascular injury.

Biomedicine & Pharmacotherapy（2018）

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摘要

•SERP1 facilities GLP-1R glycosylation in RAOECs and VSMCs.•SERP1 increases proliferation of RAOECs and inhibits the migration and proliferation of VSMCs.•SERP1 decreases the IMT and alleviates the neointimal hyperplasia in diabetic rats following carotid injury.

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关键词

SERP1,GLP-1R,Endothelial cells,Vascular smooth muscle cells,Diabetes mellitus,Vascular restenosis

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