Calcium(ii)-catalyzed enantioselective conjugate additions of amines.
CHEMICAL SCIENCE(2018)
摘要
The direct enantioselective chiral calcium(II). phosphate complex (Ca[CPA](2))-catalyzed conjugate addition of unprotected alkyl amines to maleimides was developed. This mild catalytic system represents a significant advance towards the general convergent asymmetric amination of alpha,beta-unsaturated electrophiles, providing medicinally relevant chiral aminosuccinimide products in high yields and enantioselectivities. Furthermore, the catalyst can be reused directly from a previously chromatographed reaction and still maintain both high yield and selectivity.
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关键词
enantioselective conjugate additions,calcium<scp>ii</scp>-catalyzed,amines
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