Hypoxia reduces the E-cadherin expression and increases OSCC cell migration regardless of the E-cadherin methylation profile.

Patrícia Luciana Batista Domingos,Marcela Gonçalves Souza,Talita Antunes Guimarães,Eliane Sobrinho Santos,Lucyana Conceição Farias,Carlos Alberto de Carvalho Fraga,Kimberly Marie Jones,Sérgio Henrique Souza Santos,Alfredo Maurício Batista de Paula,André Luiz Sena Guimarães

Pathology - Research and Practice（2017）

引用 18|浏览2

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摘要

The current study demonstrates that hypoxia reduces E-cadherin expression and increase cell migration, regardless of the methylation profile. Additionally, no differences in E-cadherin methylation patterns were observed among OM, PMOL and OSCC.

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关键词

Proliferation,Oral cancer,p53,HIF-1α,Caspase

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