A New Micro-holder Device for Local Drug Delivery during In Vivo Whole-cell Recordings

•Versatile and cheap device for precise and stable drug application for in vivo intracellular recordings in deep brain areas.•BMI modifies the properties of slow oscillations, changing duration, transitions and amplitude of the Up states.•Local application of TTX blocks the slow oscillations in the striatal neurons with no effects in the cortical activity.