Impact of MCT1 Haploinsufficiency on the Mouse Retina.

Neal S Peachey,Minzhong Yu,John Y S Han,Sylvain Lengacher,Pierre J Magistretti,Luc Pellerin,Nancy J Philp

RETINAL DEGENERATIVE DISEASES: MECHANISMS AND EXPERIMENTAL THERAPY（2018）

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摘要

The monocarboxylate transporter 1 (MCT1) is highly expressed in the outer retina, suggesting that it plays a critical role in photoreceptors. We examined MCT1+/- heterozygotes, which express half of the normal complement of MCT1. The MCT1(+/-) retina developed normally and retained normal function, indicating that MCT1 is expressed at sufficient levels to support outer retinal metabolism.

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关键词

MCT1,Retina,Lactate,Transgenic mice,Electroretinogram

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