Identification of novel indole based heterocycles as selective estrogen receptor modulator.

Ramit Singla, Kunal Prakash,Kunj Bihari Gupta,Shishir Upadhyay,Monisha Dhiman,Vikas Jaitak

Bioorganic Chemistry（2018）

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摘要

•Indole heterocycles were rationally designed and synthesised as SERM.•Compounds 5c and 6d reduced the mRNA and protein expression of ER-α.•Compound were able to accumulate in nucleoplasm, cytoplasm and biomembrane.•Alkyl substitution is well tolerated than aryl substitution.

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关键词

Breast cancer,Chromene,Estrogen receptor,Indole derivatives,Dihydropyridine

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