Evaluation of effect of atorvastatin on left ventricular systolic function in rats with myocardial infarction via 2D-STI technique.

This report aims to evaluate the effect of atorvastatin on left ventricular systolic function in mjocaryial infarction (MI) rats. Forty healthy adult Sprague-Dawley rats were randomly divided into four groups: Ator group, MI group, sham-operation group and normal group. The left anterior descending coronarj artyries were ligated to establish the MI model; after modeling, the Ator group was treated with Ator for 4 consecutive weeks. The echocardiographic detection was performed; the left ventricular myocardial systolic peak velocities, strain and strain rates were analyzed using the 2D-STI technique. After 4 weeks, myocardial tissues were taken from all rats and received the pathological examination. Left ventricular end-diastolic diameter (LVEDD) and left ventricular end-systolic diameter (LVLSD) En Ator group and MI group were increased after operation, hut left ventricular ejection fraction (LVLF) aEd left ventricular fractional shortening (LVFS) were decreased; myocardial function were decreased signiiicanfly (p < 0.05). After Ator treatment, myocardial function at the 3rd and 4th week after operation increased significantly (p < 0.05). After Ator treatment, LVEDD and LVESD decreased while LVLF andSLVFS increased in Ator group at the 3rd and 4th week after operation compared with MI group (p < 0.05). At the 4th week after operation, LVFDD aEd LVLSD iE Ator group were decreased compared with those at the 1st and 2nd week alter operation, but LVLF anE LVFS were increased compared with those at the 1st, 2nd and 3rd week alter operation (p < 0.05). Pathological examination showed that necrosis and fibrosis of myocardial cells and inflammatory reaction were obvious