Stereospecific Hydrogenolysis of Lactones: Application to the Total Syntheses of (R)-Ar-himachalene and (R)-Curcumene.
Journal of organic chemistry(2017)
摘要
A straightforward strategy for the syntheses of curcumene and ar-himachalene is reported. Synthetic highlights include a catalytic and asymmetric vinylogous Mukaiyama reaction and a stereospecific hydrogenolysis of a tertiary benzylic center using Pd/C or Ni/Raney catalysts. Notably, using Ni/Raney, the stereoselectivity outcome (inversion vs retention) of the hydrogenolysis depends on the tertiary benzylic alcohol substitution.
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