Induction of Nitric-Oxide Metabolism in Enterocytes Alleviates Colitis and Inflammation-Associated Colon Cancer

Julia Frug
Julia Frug
Alon Silberman
Alon Silberman
Alona Sarver
Alona Sarver
Narin N Carmel-Neiderman
Narin N Carmel-Neiderman

Cell Reports, pp. 1962-1976, 2018.

Cited by: 7|Views18
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Abstract:

Nitric oxide (NO) plays an established role in numerous physiological and pathological processes, but the specific cellular sources of NO in disease pathogenesis remain unclear, preventing the implementation of NO-related therapy. Argininosuccinate lyase (ASL) is the only enzyme able to produce arginine, the substrate for NO generation by...More

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