Discovery of novel N-hydroxy-2-arylisoindoline-4-carboxamides as potent and selective inhibitors of HDAC11.

Matthew W Martin,Jennifer Y Lee,David R Lancia,Pui Yee Ng, Bingsong Han,Jennifer R Thomason, Maureen S Lynes,C Gary Marshall, Chiara Conti,Alan Collis, Monica Alvarez Morales, Kshama Doshi, Aleksandra Rudnitskaya,Lili Yao,Xiaozhang Zheng

Bioorganic & Medicinal Chemistry Letters（2018）

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摘要

•Identified novel, potent, and selective first-in-class inhibitors of HDAC11.•Synthesis and structure activity relationships of compounds are reported.•FT895 displays promising cellular activity and pharmacokinetic properties.•FT895 is a valuable tool for further study of the biology of HDAC11.

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关键词

HDAC11,HDACs,Oncology,Inflammation,Isoindoline,Hydroxamic acid

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