Hand, shoulder and back stiffness in long-term type 1 diabetes; cross-sectional association with skin collagen advanced glycation end-products. The Dialong study

Journal of Diabetes and its Complications(2017)

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摘要
•Persons with T1DM >45 years had a very high lifetime prevalence of hand and shoulder diagnoses versus controls.•We found an association between joint stiffness and both skin collagen Advanced Glycation End-products and HbA1c.•Our results imply that the pathogenesis for stiffness formation differs from that leading to microvascular complications.
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关键词
Long-term complications,Type 1 diabetes mellitus,Advanced glycation end-products,Musculoskeletal disorders,Hemoglobin A,Glycosylated
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