A Chimeric Mutant Analysis In Yeast Cells Suggests Bip Independent Regulation Of The Mammalian Endoplasmic Reticulum-Stress Sensor Ire1
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY(2018)
摘要
An endoplasmic reticulum (ER)-located transmembrane protein, Ire1, triggers cytoprotective events upon ER stress. Chimeric yeast Ire1 carrying the luminal domain of the mammalian major Ire1 paralogue IRE1 is upregulated in ER-stressed yeast cells, but is poorly associated with the ER-located chaperone BiP even under non-stressed conditions. This observation contradicts the theory that BiP is the master regulator of IRE1.
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关键词
unfolded protein response, molecular chaperone, stress response, stress sensing, organelle
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