TNF-α Exerts Potent Anti-rotavirus Effects via the Activation of Classical NF-κB Pathway.

•TNF-α has potent anti-rotavirus effects.•Anti-rotavirus effects of TNF-α is independent of type I interferon production.•The anti-rotavirus effect of TNF-α was achieved by NFκB-regulated genes via the activation of classical nuclear factor κB (NF-κB) signaling.